Gilbert Lab

Engineering the Epigenome

Arc Institute UCSF Helen Diller Cancer Center
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Research

Epigenome Engineering

CRISPRi, CRISPRa, and CRISPRoff for programmable control of gene expression without cutting DNA.

Functional Genomics

Genome-scale screens to map genetic interactions and identify synthetic lethal targets in cancer.

Single-Cell / Perturb-seq

High-throughput screens to map transcriptional responses across phenotypes and diverse cell types.

Drug Resistance

Modeling therapy response in prostate cancer, AML, glioblastoma, and lung cancer.

COMET / Effector Discovery

High-throughput screening of combinatorial dCas9 effector fusions to discover transcriptional modulators and map domain interactions.

Combinatorial Perturbations

Engineered Cas12a for multiplexed chromatin editing and higher-order genetic interactions.

Team

Our People

Luke Gilbert

Luke Gilbert

Principal Investigator

Associate Professor at UCSF and Core Investigator at Arc Institute. PhD from MIT. Developed CRISPRi/a with Jonathan Weissman. NIH New Innovator. Pew-Stewart Scholar.

Email Scholar UCSF

Scientists & Postdocs

Gary Wang
Gary Wang
Scientist
Kewa Gao
Kewa Gao
Scientist
Sarah Hsu
Sarah Hsu
Fellow
Tyler Fair
Tyler Fair
Scientist

Graduate Students

Ashir Borah
Ashir Borah
Graduate Student
Caroline Wilson
Caroline Wilson
Graduate Student

Staff

Ishwa Muzaffery
Ishwa Muzaffery
Lab Manager
Mandy Sun
Mandy Sun
Lab Technician

Publications

Selected Work

View all publications →

Lab Life

Celebrations & Milestones

Holiday Lunch 2025
Dec 17, 2025
Holiday Lunch 2025
& of course our annual white elephant
Laine's PhD Graduation
Nov 14, 2025
Laine's PhD Graduation
Congratulations Dr. Goudy!
Graduations & Farewells
Mar 24, 2025
Graduations & Farewells
Celebrating multiple milestones
Lunar New Year
Feb 7, 2025
Lunar New Year Happy Hour
Gong hei fat choi!
White Elephant 2024
Dec 13, 2024
White Elephant 2024
Annual holiday gift exchange
Lab Outing 2024
Jul 18, 2024
Lab Outing 2024
Summer lab gathering
Ashir Passed Quals
Mar 4, 2024
Ashir Passed Quals
Congratulations Ashir!
Lunar New Year 2024
Feb 9, 2024
Lunar New Year 2024
Happy Lunar New Year from Arc!
White Elephant & Baby Shower
Dec 8, 2023
White Elephant & Baby Shower
Dual celebration for Sarah
Go Kart Racing
Nov 29, 2023
Go Kart Racing
K1 Speed lab outing
Candle Making
Aug 25, 2023
Candle Making Happy Hour
Creative lab social
Amanda's Exit Talk
Aug 11, 2023
Amanda's Exit Talk
Farewell and best wishes!

Resources

Protocols & Tools

Alumni

Where Are They Now

Aidan Winters
Scientist II, Neptune Bio
Alex Ge
2017-2019 · Medical Student, UCSF
Amanda Chung
2019-2023 · Editas Medicine
Becky Fu
Scientist, Acrobat Genomics
Ben Herken
Scientist, Xiara Therapeutics
Chris Hsiung
Assistant Professor, UCSF
Chris Yogodzinski
2018-2020 · Graduate Student, UNC
Garrett Wong
Greg Pommier
2020-2022 · Medical Student, Johns Hopkins
Haolong Li
Assistant Professor, Fred Hutch
Jason Estep
Senior Scientist, Terremoto Biosciences
Jason Swindermann
Medical School, MD/PhD, UCSF
John Liu
Assistant Professor, UCSF
Laine Goudy
Scientist, Xiara Therapeutics
Lilly Scheibe
2019-2021 · Harvard Medical School
Nicholas Sambold
Graduate Student, Stanford
Raymond Dai
Data Acquisition & Architecture, Eli Lilly and Company
Sara Misiukiewicz
2020-2022 · Graduate Student, UCSF
Shaheen Kabir
2018-2021 · Graphite Bio
Tom O'Loughlin
2019-2022 · Assistant Professor, Mount Sinai

Join Us

We're Recruiting

We're looking for motivated postdocs, graduate students, and research associates to join our team.

Get in Touch
Location
Arc Institute
3181 Porter Drive
Palo Alto, CA 94304
Email
luke [at] arcinstitute.org
Affiliations
Arc Institute
UCSF